Bipolar disorder: Functional neuroimaging markers in relatives.

摘要: Neural models of anatomical and functional alterations have been proposed for bipolar disorders (BD). However, studies in affected patients do not allow disentangling linked to the liability BD from those associated with evolution, medication comorbidities BD. Explorations high risk subjects study these markers. We reported summarized all magnetic resonance imaging (fMRI) focusing on first-degree relatives patients. found 29 reporting neural correlates working memory (WM), emotional processing, executive functions resting state patients, compared healthy subjects. Overall, same regions that involved such as inferior frontal gyrus limbic areas, seem be functionally altered high-risk conclude brain already implicated pathophysiology disease amygdala are also However longitudinal required understand their implication transition