Dual pH- and temperature-responsive RAFT-based block co-polymer micelles and polymer–protein conjugates with transient solubility
作者： Qilu Zhang , Nane Vanparijs , Benoit Louage , Bruno G. De Geest , Richard Hoogenboom
DOI: 10.1039/C3PY00971H
关键词:
摘要: Via a smart combination of temperature-responsive and acid labile acetal monomers, copolymers are obtained with la carte lower critical solution temperature behavior. RAFT copolymerization these monomers using, respectively, PEG-functionalized or amine-reactive NHS-functionalized chain transfer agent allows designing micelles polymer–protein conjugates transient solubility properties within physiologically relevant window.
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