Evaluation of vancomycin-based synergistic system with amino acid ester chiral ionic liquids as additives for enantioseparation of non-steroidal anti-inflamatory drugs by capillary electrophoresis

摘要: Abstract Recently, chiral ionic liquids (ILs) have drawn increasing attention in separation field; however, few papers reported the application of ILs for by capillary electrophoresis (CE), and among papers, were mainly applied as additives to β-cyclodextrin derivatives systems establish synergistic systems. The system based on antibiotics with has never been before. In this paper, two amino acid ester, l -alanine -valine tert butyl ester bis (trifluoromethane) sulfonamide, first evaluate effect antibiotic selector CE separation. vancomycin-based was successfully established investigated enantioseparation naproxen, carprofen, ibuprofen, ketoprofen pranoprofen. Compared vancomycin-alone cases, significant improvement all analytes observed. Several parameters, such type proportion organic modifier, composition pH buffer, concentration vancomycin systematically investigated, then evaluated means Statistical Product Service Solutions (SPSS) research influences effect. Finally, method test impurity naproxen sample.