Chondral defect repair after the microfracture procedure: a nonhuman primate model.

摘要: BackgroundThe extent and time course of chondral defect healing after microfracture in humans are not well described. Although most physicians recommend a period activity weightbearing restriction to protect the cartilage, there limited data on which base decisions regarding duration such restrictions.HypothesisEvaluation status repair at different points primate model may provide rationale for postoperative recommendations.Study DesignDescriptive laboratory study.MethodsFull-thickness defects created femoral condyles trochlea 12 cynomolgus macaques were treated with evaluated by gross histologic examination 6 weeks.ResultsAt weeks, was ongoing resorption subchondral bone. By completely filled showed more mature cartilage bone repair.ConclusionIn animal model, significant ...