Permeability of the blood-retinal barrier to carboxyfluorescein in eyes with rhegmatogenous retinal detachment.
作者： Shunji Tsuboi , Jonathan E. Pederson
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摘要: Outward and inward permeability of carboxyfluorescein across the blood-retinal barrier were measured fluorophotometrically in seven cynomolgus monkey eyes with experimental rhegmatogenous retinal detachment. Probenecid was used to inhibit outward transport carboxyfluorescein. The 1.98 +/- 0.31 microliter/min detachment 0.84 0.15 control vitrectomy alone (P less than 0.01). permeability, determined separately following intravenous injection, significantly lower permeability: 0.14 0.02 for 0.04 0.01 eyes. Since minus presence probenecid represents that fraction tracer moving due fluid flow, it may be concluded flow is a substantial contributor loss from vitreous cavity intravitreal injection.
arvojournals.org参考文章(22)
S Tsuboi, J E Pederson, Permeability of the isolated dog retinal pigment epithelium to carboxyfluorescein. Investigative Ophthalmology & Visual Science. ,vol. 27, pp. 1767- 1770 ,(1986)
M F Marmor, A Negi, Quantitative estimation of metabolic transport of subretinal fluid. Investigative Ophthalmology & Visual Science. ,vol. 27, pp. 1564- 1568 ,(1986)
K Emi, R Manabe, K Kishida, S Iizuka, Y Uchihori, S Tsuboi, T Fujimoto, Measurement of retinal permeability to sodium fluorescein in vitro. Investigative Ophthalmology & Visual Science. ,vol. 25, pp. 1146- 1150 ,(1984)
Makoto Araie, Aqueous Humor Dynamics in Man as Studied by Oral Fluorescein Japanese Journal of Ophthalmology. ,vol. 24, pp. 346- 362 ,(1980)
A. Katchalsky, Peter F. Curran, Nonequilibrium Thermodynamics in Biophysics ,(1965)
D.A. Frambach, J.J. Weiter, A.J. Adler, A photogrammetric method to measure fluid movement across isolated frog retinal pigment epithelium. Biophysical Journal. ,vol. 47, pp. 547- 552 ,(1985) , 10.1016/S0006-3495(85)83949-7
F. Johnson, D. Maurice, A simple method of measuring aqueous humor flow with intravitreal fluoresceinated dextrans. Experimental Eye Research. ,vol. 39, pp. 791- 805 ,(1984) , 10.1016/0014-4835(84)90078-2
Jonathan E. Pederson, Experimental retinal detachment. II. Role of the vitreous. Archives of Ophthalmology. ,vol. 100, pp. 1155- 1159 ,(1982) , 10.1001/ARCHOPHT.1982.01030040133024
Shunji Tsuboi, Experimental Retinal Detachment: X. Effect of Acetazolamide on Vitreous Fluorescein Disappearance Archives of Ophthalmology. ,vol. 103, pp. 1557- 1558 ,(1985) , 10.1001/ARCHOPHT.1985.01050100133034
E Taylor, A Jennings, Calculation of total retinal area. British Journal of Ophthalmology. ,vol. 55, pp. 262- 265 ,(1971) , 10.1136/BJO.55.4.262