Combination Analysis of Genetic Alterations and Cell Proliferation in Small Intestinal Carcinomas
作者： Tsuyoshi Muneyuki , Masatoshi Watanabe , Mikio Yamanaka , Shuji Isaji , Yoshifumi Kawarada
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摘要: We analyzed K-ras and p53 mutations, microsatellite instability (MSI), loss of heterozygosity (LOH) using the polymerase chain reaction (PCR) methods, as well expression Ki-67 labeling index (LI) immunohistochemistry in 10 duodenal jejunal/ileal carcinomas. mutations were detected two (20%) three (30%) carcinomas one (10%) (30%), respectively. LOH 17p was four (40%) (40%). One demonstrated MSI. APC but none The LI 44% 52.6% A subset small intestinal showed involvement APC, difference also apparent for between
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