L’utilizzo delle DDD reference based per la valutazione della compliance terapeutica nel trattamento con statine

摘要: Compliance is crucial in the treatment with statins. It generally evaluated by comparing daily dose received on average treated patients a standard parameter, which often corresponding DDD (Defined Daily Dose) issued WHO (World Health Organisation). As regards statins, DDDs (which will be hereafter referred to as WHO-DDDs) have shown poor indicators of correct dosing they underestimate). an alternative evaluation standard, reference based were drawn, for this study, from NCEP (National Cholesterol Education Program) guidelines, i.e. progress clinical research efficacy and safety This multicenter, retrospective study statistical sample including six ASLs (ASL: Azienda Sanitaria Locale, Local Unit), located many Italian Regions, whole providing health care 2,625,000 people. Subjects eligible whom statins had been prescribed at least once period 2001–2005 (observation period). Data relative 294,295 selected ASL administrative databases. Sampled aged 61 48% males. The patient’s compliance (measured ratio between DDD) increased less than 40% more 50% observation period. (Had WHO-DDDs, analogous values would 85% 100%). was analysed through appropriateness bands. In particular, frequency quite incorrectly-treated (compliance up 25%) decreased 65% sample, while optimal band (75% 100% compliance) soared 3% 10%. chosen availability reliability criteria, resulted their being concentrated Northern-Central part Italy (with Marche Region weighing half sample). They could nevertheless considered fairly representative country. constantly improved during period, even if it reached (only) overall 2005. If WHO-DDDs used, too optimistically evaluated, suggesting over-treatment area (resulting high included compliance).