Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders

摘要: Monoamine oxidase (MAO) enzyme catalyzes the oxidative deamination of xenobiotic and endogenous amines including many neurotransmitters. The MAO exists in two isoforms; MAO-A MAO-B these isoforms display considerable sequence similarity but differ tissue distribution, inhibitor selectivity specificity towards ligands. altered concentration neurotransmitters brain is linked with biochemical pathology various neurological disorders depression, Alzheimer's disease Parkinson's disease. inhibitors were first antidepressants discovered their irreversible binding to resulted a number side effects fatal food–drug interactions. new generation inhibitors, especially reversible selective less toxic found be effective against disorders. Now has been recognised as an important drug target are being developed candidates for management depression anxiety disorders, whereas treatment better safety profile compared nonselective inhibitors. current review article describes recent developments on design, synthesis screening structure–activity relationship studies, role etiology