Inflammation markers, chronic kidney disease, and renal replacement therapy.

摘要: Chronic kidney disease (CKD) is associated with a proinflammatory state and an excess of cardiovascular risk. In this work, we describe changes in inflammatory markers-C-reactive protein (CRP), pentraxin 3 (PTX3), serum component amyloid A (SAA), procalcitonin (PCT)--in CKD patients compared control group subjects normal estimated glomerular filtration rate (eGFR). Blood samples were obtained from 69 healthy individuals (GP) 70 end-stage patients--25 not yet on dialysis, 22 peritoneal dialysis (PD), 23 hemodialysis (HD). These the results [median (95% confidence interval)] for GP CKD, PD, HD groups respectively: CRP: 1.40 mg/L (1.19-2.11 mg/L), 6.50 (3.57-8.32mg/L), 7.60 (2.19-22.10mg/L), 9.60 (6.62-16.38 mg/L). SAA: 3.10 (2.90-3.53 7.11 (3.81-15.40mg/L), 9.69 (5.07-29.47mg/L), 15.90 (6.80-37.48 PCT: 0.03 ng/mL (0.02-0.03 ng/mL), 0.12 (0.09-0.16 0.32 (0.20-0.46 ng/ mL), 0.79 (0.45-0.99 ng/mL). PTX3: 0.54 (0.33-0.62 0.71 mL (0.32-1.50 1.52 (0.65-2.13 1.67 (1.05-2.27 Compared levels group, SAA CRP (systemic response) significantly higher dialysis. Levels PTX3 only dialyzed patients, so those (greatly different levels). differing might be related to local reaction caused by invasive intervention (PD or HD). As eGFR declines start renal replacement therapy, PCT increases. could potentially cause confusion when these are being evaluated presence infection, may also demonstrate some microvascular implications therapy.