Radiosurgical boost for primary high-grade gliomas.

摘要: The purpose of this study was to retrospectively evaluate the survival patients with high-grade gliomas treated external beam radiotherapy or without radiosurgical boost. From July 1993 April 1998, 32 were selected, 15 which received radiosurgery. Inclusion criteria age >18 years, histological confirmation glioma, primary tumor treatment curative intent, unifocal and supratentorial location. All found be in classes III–VI, according recursive partitioning analysis proposed by Radiation Therapy Oncology Group. median interval between radiosurgery 5 weeks (range 1–13). Treatment volumes ranged from 2.9 70.3 cc (median 15.0 cc). Prescribed doses varied 8.0 12.5 Gy 10.0 Gy). Radiosurgery control groups well balanced respect prognostic factor distributions. Median actuarial time 21.4 months 11.6 months, respectively (p=0.0254). Among KPS≥80, 11.0 53.9 groups, (p=0.0103). single correlated on Cox model (p=0.0362) associated a 2.76 relative reduction risk cancer death (95% confidence (CI) 1.07–7.13). Our results suggest that may confer advantage for RPA especially those Karnofsky performance status ≥80. definitive role boost awaits randomized trials.