Ketosis and appetite-mediating nutrients and hormones after weight loss

摘要: Diet-induced weight loss is accompanied by compensatory changes, which increase appetite and encourage regain. There some evidence that ketogenic diets suppress appetite. The objective to examine the effect of ketosis on a number circulating factors involved in regulation, following diet-induced loss. Of 50 non-diabetic overweight or obese subjects who began study, 39 completed an 8-week very-low-energy diet (VLED), followed 2 weeks reintroduction foods. Following loss, concentrations glucose, insulin, non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHB), leptin, gastrointestinal hormones subjective ratings were compared when ketotic, after refeeding. During VLED, lost 13% initial fasting BHB increased from (mean±s.e.m.) 0.07±0.00 0.48±0.07 mmol/l (P<0.001). fell 0.19±0.03 mmol/l refeeding (P<0.001 with week 8). When participants induced ghrelin was suppressed. Glucose NEFA higher, amylin, leptin lower at 8 than several nutrients influence altered diet, accompany dietary reduction mitigated weight-reduced ketotic.