Maintenance Immunosuppression in Kidney Transplantation

摘要: Immunosuppressive therapy is a critical component for successful kidney transplantation. More intensive immunosuppression required in the first posttransplant months when risk of rejection greatest, followed by progressive reduction stable patients to minimize toxicity. The most common maintenance immunosuppressive agents can be divided into five categories: corticosteroids, calcineurin inhibitors, antiproliferative agents, mammalian target rapamycin and costimulation blockers. For renal transplant recipients generally consists combination inhibitor an agent, with or without corticosteroids. Regimens designed limit avoid inhibitors and/or corticosteroids setting are being investigated attempt reduce long-term drug-related toxicity improve allograft outcomes.