Sympathetic Nervous System Modulation of Inflammation and Remodeling in the Hypertensive Heart
作者： Scott P. Levick , David B. Murray , Joseph S. Janicki , Gregory L. Brower
DOI: 10.1161/HYPERTENSIONAHA.109.142042
关键词:
摘要: Chronic activation of the sympathetic nervous system is a key component cardiac hypertrophy and fibrosis. However, previous studies have provided evidence that also implicate inflammatory cells, including mast cells (MCs), in development The current study investigated potential interaction MCs with system. Eight-week-old male spontaneously hypertensive rats were sympathectomized to establish effect on MC density, myocardial remodeling, cytokine production heart. Age-matched Wistar Kyoto served as controls. Cardiac fibrosis hypertension significantly attenuated left ventricular mass normalized, whereas density was markedly increased rats. Sympathectomy normalized levels interferon-gamma, interleukin 6, 10, but had no 4. effects norepinephrine substance P isolated mechanisms between two. Only elicited degranulation. Substance shown induce angiotensin II by mixed population MCs, lymphocytes, macrophages. These results demonstrate ability neuropeptides regulate cell function, providing mechanism which afferent nerves may interact
sci-hub.se 参考文章(34)
S. Fallarini, S. Perlini, A. Bertolotti, R. Tozzi, S. Miserere, G. Palladini, A. Facoetti, Rosanna Nano, C. Gatti, I. Ferrero, Histochemical study of cardiac mast cells degranulation and collagen deposition: interaction with the cathecolaminergic system in the rat. European Journal of Histochemistry. ,vol. 50, pp. 133- 140 ,(2006) , 10.4081/985
M. Steinhoff, N. Vergnolle, S.H. Young, M. Tognetto, S. Amadesi, H.S. Ennes, M. Trevisani, M.D. Hollenberg, J.L. Wallace, G.H. Caughey, S.E. Mitchell, L.M. Williams, P. Geppetti, E.A. Mayer, N.W. Bunnett, Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism Nature Medicine. ,vol. 6, pp. 151- 158 ,(2000) , 10.1038/72247
Jean-Pierre Kinet, The essential role of mast cells in orchestrating inflammation Immunological Reviews. ,vol. 217, pp. 5- 7 ,(2007) , 10.1111/J.1600-065X.2007.00528.X
K S Madden, V M Sanders, D L Felten, Catecholamine Influences and Sympathetic Neural Modulation of Immune Responsiveness Annual Review of Pharmacology and Toxicology. ,vol. 35, pp. 417- 448 ,(1995) , 10.1146/ANNUREV.PA.35.040195.002221
J.A. Kessler, J.E. Adler, W.O. Bell, I.B. Black, Substance p and somatostatin metabolism in sympathetic and special sensory ganglia in vitro Neuroscience. ,vol. 9, pp. 309- 318 ,(1983) , 10.1016/0306-4522(83)90296-8
Alicia C. Reid, Randi B. Silver, Roberto Levi, Renin: at the heart of the mast cell Immunological Reviews. ,vol. 217, pp. 123- 140 ,(2007) , 10.1111/J.1600-065X.2007.00514.X
Satoshi Kagitani, Hitoshi Ueno, Satoshi Hirade, Toru Takahashi, Masanobu Takata, Hiroshi Inoue, Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats. Journal of Hypertension. ,vol. 22, pp. 1007- 1015 ,(2004) , 10.1097/00004872-200405000-00024
S.T. Meller, G.F. Gebhart, A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain Neuroscience. ,vol. 48, pp. 501- 524 ,(1992) , 10.1016/0306-4522(92)90398-L
Qianli Yu, Ronald R. Watson, John J. Marchalonis, Douglas F. Larson, A role for T lymphocytes in mediating cardiac diastolic function. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 289, ,(2005) , 10.1152/AJPHEART.00073.2005
Abraham P. Provoost, Wybren De Jong, Differential development of renal, DOCA-salt, and spontaneous hypertension in the rat after neonatal sympathectomy. Clinical and Experimental Hypertension. ,vol. 1, pp. 177- 189 ,(1978) , 10.3109/10641967809068603