Do glial cells control pain
作者： Marc R. Suter , Yeong-Ray Wen , Isabelle Decosterd , Ru-Rong Ji
DOI: 10.1017/S1740925X08000100
关键词:
摘要: Management of chronic pain is a real challenge, and current treatments focusing on blocking neurotransmission in the pathway have only resulted limited success. Activation glia cells has been widely implicated neuroinflammation central nervous system, leading to neruodegeneration many disease conditions such as Alzheimer’s multiple sclerosis. The inflammatory mediators released by activated glial cells, tumor necrosis factor-α interleukin-1β can not cause neurodegeneration these conditions, but also abnormal acting spinal cord dorsal horn neurons injury conditions. Pain be potentiated growth factors BDNF bFGF that are produced protect neurons. Thus, powerfully control when they produce various mediators. We will review accumulating evidence supporting an important role microglia for under (e.g. nerve injury). discuss possible signaling mechanisms particular MAP kinase pathways critical pain. Investigating may lead more effective management devastating
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