Aggregation, stability, and formulation of human antibody therapeutics
作者： D. Lowe , K. Dudgeon , R. Rouet , P. Schofield , L. Jermutus
DOI: 10.1016/B978-0-12-386483-3.00004-5
关键词:
摘要: Many human monoclonal antibodies display poor biophysical properties, such as low stability and a propensity to aggregate. These unfavorable tendencies can be even more pronounced for antibody fragments, which often require considerable degree of optimization. In this review, we describe methods analyzing aggregation fragments. We also provide an overview recent approaches improve these properties through engineering formulation.
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