Microbiota-Based Therapies for Clostridium difficile and Antibiotic-Resistant Enteric Infections

摘要: Bacterial pathogens are increasingly antibiotic resistant, and development of clinically effective antibiotics is lagging. Curing infections requires antimicrobials that broader spectrum, more toxic, expensive, mortality attributable to antibiotic-resistant rising. The commensal microbiota, comprising microbes colonize the mammalian gastrointestinal tract, can provide high levels resistance infection, contributions specific bacterial species being discovered characterized. Microbiota-mediated mechanisms colonization pathogen clearance include bactericidal activity, nutrient depletion, immune activation, manipulation gut's chemical environment. Current research focusing on microbiota-based therapies reduce intestinal with pathogens, goal reducing transmission systemic dissemination.