Association of Histopathological Markers with Clinico-Pathological Factors in Mexican Women with Breast Cancer

摘要: BACKGROUND Breast cancer (BCa) is the most common malignancy in Mexican women. A set of histopathological markers has been established to guide BCa diagnosis, prognosis and treatment. Nevertheless, only a few health services, such as that Secretariat National Defense (SEDENA for its acronym Spanish), are these commonly employed assessing BCa. The aim this study was explore association Ki67, TP53, HER2/neu, estrogenic receptors (ERs) progesterone (PRs) with risk factors. MATERIALS AND METHODS Clinical histories provided background patient information. Immunohistochemical (IHC) analysis conducted on 48 tissue samples from women diagnosed treated radical mastectomy. Chi square test or Fisher exact together Pearson Spearman correlation were applied. RESULTS On average, patients 58±10.4 years old. It find invasive ductal carcinoma (95.8%), histological grade 3 (45.8%), poor Nottingham Prognostic Index (NPI; 80.4%). ERs PRs associated smoking alcohol consumption, metastasis at diagnosis Ki67 expression (p<0.05). PR+ also related urea ER+ TP53 elevated triglycerides (p<0.05), HER2/neu ER+, number pregnancies tumor size NPI (p <0.05) CD34 triple negative status (ER-/PR-/HER2/neu-) smoking, exposure biomass, pregnancies, Moreover, luminal B subtype type (p=0.007), (p=0.03) high cholesterol (p=0.02). CONCLUSIONS ER PR proved be several clinical pathological Hence, it crucial determine IHC profile Certain associations require further understand physiological/biochemical/molecular processes.