Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis.

作者: Xiaoyan Tang , Ruoqi Peng , Jonathan E. Phillips , Jeremy Deguzman , Yonglin Ren

DOI: 10.1016/J.AJPATH.2013.04.020

关键词:

摘要: … Brd4 in the development of experimental models of sepsis, 18 multiple myeloma, 29 and chronic kidney disease… inhibition of Brd4 after systemic administration in mice of Brd4 small …

参考文章(37)
Roberto Sanchez, Ming-Ming Zhou, The role of human bromodomains in chromatin biology and gene transcription. Current Opinion in Drug Discovery & Development. ,vol. 12, pp. 659- 665 ,(2009)
Carlo Vancheri, Idiopathic pulmonary fibrosis: an altered fibroblast proliferation linked to cancer biology. Proceedings of the American Thoracic Society. ,vol. 9, pp. 153- 157 ,(2012) , 10.1513/PATS.201203-025AW
Kazuhisa Konishi, Kevin F. Gibson, Kathleen O. Lindell, Thomas J. Richards, Yingze Zhang, Rajiv Dhir, Michelle Bisceglia, Sebastien Gilbert, Samuel A. Yousem, Jin Woo Song, Dong Soon Kim, Naftali Kaminski, Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. ,vol. 180, pp. 167- 175 ,(2009) , 10.1164/RCCM.200810-1596OC
Guangtao Zhang, Ruijie Liu, Yifei Zhong, Alexander N. Plotnikov, Weijia Zhang, Lei Zeng, Elena Rusinova, Guillermo Gerona-Nevarro, Natasha Moshkina, Jennifer Joshua, Peter Y. Chuang, Michael Ohlmeyer, John Cijiang He, Ming-Ming Zhou, Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition Journal of Biological Chemistry. ,vol. 287, pp. 28840- 28851 ,(2012) , 10.1074/JBC.M112.359505
Cory M. Hogaboam, Matthew L. Steinhauser, Stephen W. Chensue, Steven L. Kunkel, Novel roles for chemokines and fibroblasts in interstitial fibrosis Kidney International. ,vol. 54, pp. 2152- 2159 ,(1998) , 10.1046/J.1523-1755.1998.00176.X
Edwige Nicodeme, Kate L. Jeffrey, Uwe Schaefer, Soren Beinke, Scott Dewell, Chun-wa Chung, Rohit Chandwani, Ivan Marazzi, Paul Wilson, Hervé Coste, Julia White, Jorge Kirilovsky, Charles M. Rice, Jose M. Lora, Rab K. Prinjha, Kevin Lee, Alexander Tarakhovsky, Suppression of inflammation by a synthetic histone mimic Nature. ,vol. 468, pp. 1119- 1123 ,(2010) , 10.1038/NATURE09589
Gustavo Ramírez, James S Hagood, Yan Sanders, Remedios Ramírez, Carina Becerril, Lourdes Segura, Lourdes Barrera, Moisés Selman, Annie Pardo, Absence of Thy-1 results in TGF-β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts Laboratory Investigation. ,vol. 91, pp. 1206- 1218 ,(2011) , 10.1038/LABINVEST.2011.80
R.K. Prinjha, J. Witherington, K. Lee, Place your BETs: the therapeutic potential of bromodomains Trends in Pharmacological Sciences. ,vol. 33, pp. 146- 153 ,(2012) , 10.1016/J.TIPS.2011.12.002
K B Baumgartner, J M Samet, C A Stidley, T V Colby, J A Waldron, Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. ,vol. 155, pp. 242- 248 ,(1997) , 10.1164/AJRCCM.155.1.9001319