作者: Ingeborg M. Bajema , Jan A. Bruijn , Alina Casian , Maria C. Cid , Elena Csernok
DOI: 10.1016/J.EKIR.2017.09.008
关键词:
摘要: The 2016 European Vasculitis Society (EUVAS) meeting, held in Leiden, the Netherlands, was centered around phenotypic subtyping antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). There were parallel meetings of EUVAS petals, which here report on disease assessment; database; and long-term follow-up, registries, genetics, histology, biomarker studies, clinical trials. Studies currently conducted will improve our ability to discriminate between different forms vasculitis. In a project that involves 10-year follow-up AAV patients, we are working retrieving data patient renal survival, relapse rate, cumulative incidence malignancies, comorbidities. Across Europe, several registries developed covering over 10,000 registered patients. near future, these facilitate research scale hitherto unknown. Current studies genetic background explore potential prognostic significance markers further refine associations with distinct subsets. histopathological classification ANCA-associated glomerulonephritis is evaluated light coming out large international validation study. continuous search for biomarkers predict outcome, promising new important subjects current research. Over last 2 decades, host trials have provided evidence refinement therapeutic regimens. We give an overview under development, consider refractory detail. goal stimulate ongoing clinical, serological, histological management techniques patients systemic vasculitis, outlook applicability