Impact of a nonuniform charge distribution on virus assembly
作者： Siyu Li , Gonca Erdemci-Tandogan , Jef Wagner , Paul van der Schoot , Roya Zandi
DOI: 10.1103/PHYSREVE.96.022401
关键词:
摘要: Many spherical viruses encapsulate their genomes in protein shells with icosahedral symmetry. This process is spontaneous and driven by electrostatic interactions between positive domains on the virus coat proteins negative genomes. We model effect of nonuniform charge distribution from shell instead using a mean-field theory. find that this strongly affects optimal genome length it can explain experimentally observed phenomenon overcharging viruslike particles.
harvard.edu
arxiv.org
tue.nl参考文章(43)
J.B. Bancroft, The Self-Assembly Of Spherical Plant Viruses Advances in Virus Research. ,vol. 16, pp. 99- 134 ,(1970) , 10.1016/S0065-3527(08)60022-6
R. F. Bruinsma, Physics of RNA and viral assembly European Physical Journal E. ,vol. 19, pp. 303- 310 ,(2006) , 10.1140/EPJE/I2005-10071-1
Szilard N. Fejer, Dwaipayan Chakrabarti, David J. Wales, Emergent complexity from simple anisotropic building blocks: shells, tubes, and spirals. ACS Nano. ,vol. 4, pp. 219- 228 ,(2010) , 10.1021/NN9013565
D. C. Rapaport, Self-assembly of polyhedral shells: A molecular dynamics study Physical Review E. ,vol. 70, pp. 051905- ,(2004) , 10.1103/PHYSREVE.70.051905
Jef Wagner, Roya Zandi, The Robust Assembly of Small Symmetric Nanoshells Biophysical Journal. ,vol. 109, pp. 956- 965 ,(2015) , 10.1016/J.BPJ.2015.07.041
Ting Chen, Zhenli Zhang, Sharon C. Glotzer, A precise packing sequence for self-assembled convex structures Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 717- 722 ,(2007) , 10.1073/PNAS.0604239104
Stefan Paquay, Halim Kusumaatmaja, David J. Wales, Roya Zandi, Paul van der Schoot, Energetically favoured defects in dense packings of particles on spherical surfaces Soft Matter. ,vol. 12, pp. 5708- 5717 ,(2016) , 10.1039/C6SM00489J
J. Sun, C. DuFort, M.-C. Daniel, A. Murali, C. Chen, K. Gopinath, B. Stein, M. De, V. M. Rotello, A. Holzenburg, C. C. Kao, B. Dragnea, Core-controlled polymorphism in virus-like particles Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 1354- 1359 ,(2007) , 10.1073/PNAS.0610542104
Remy Kusters, Hsiang-Ku Lin, Roya Zandi, Irina Tsvetkova, Bogdan Dragnea, Paul van der Schoot, Role of charge regulation and size polydispersity in nanoparticle encapsulation by viral coat proteins Journal of Physical Chemistry B. ,vol. 119, pp. 1869- 1880 ,(2015) , 10.1021/JP5108125
Michael F Hagan, Roya Zandi, Recent advances in coarse-grained modeling of virus assembly arXiv: Biomolecules. ,(2016) , 10.1016/J.COVIRO.2016.02.012