Renin-Angiotensin System - Considerations for Hypertension and Kidney

摘要: The kidneys play a fundamental role in the long-term control of arterial pressure by regulating sodium balance and extracellular fluid volume. renin-angiotensin system (RAS) is at center regulation hypertension progressive renal injury. It has gradually become clear that not only systemic RAS, but also intrarenal RAS specific effects pathogenesis progression damage. All components are exhibited kidney angiotensin II (Ang II) formed multiple mechanisms. demonstration much enhanced levels Ang within compartments points out selective local kidney, showing regulated way different from circulating II. importance involving proper nephrogenesis well known, suppression during fetal development may key mediating structural physiological changes observed models programming hypertension.