Spatial Distributions of Guest Molecule and Hydration Level in Dendrimer-Based Guest–Host Complex
作者： Chih-Ying Liu , Hsin-Lung Chen , Changwoo Do , Kunlun Hong
DOI: 10.1021/ACSMACROLETT.6B00526
关键词:
摘要: Using the electrostatic complex of G4 poly(amidoamine) (PAMAM) dendrimer with an amphiphilic surfactant as a model system, contrast variation small angle neutron scattering (SANS) is implemented to resolve key structural characteristics dendrimer-based guest–host system. Quantifications radial distributions length density and hydration level within molecule reveal that embedded in peripheral region steric crowding this increases backfolding dendritic segments, thereby reducing throughout molecule. The insights into spatial location guest molecules well perturbations conformation deduced here are crucial for delicate design system biomedical applications.
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sci-hub.se 参考文章(28)
W. Wiegand, Density fluctuations and the state of order of amorphous polymers Steinkopff. pp. 355- 366 ,(1979) , 10.1007/BFB0117367
Yiyun Cheng, Qinglin Wu, Yiwen Li, Jingjing Hu, Tongwen Xu, New insights into the interactions between dendrimers and surfactants: 2. Design of new drug formulations based on dendrimer-surfactant aggregates. Journal of Physical Chemistry B. ,vol. 113, pp. 8339- 8346 ,(2009) , 10.1021/JP9021618
Scott H. Medina, Mohamed E. H. El-Sayed, Dendrimers as carriers for delivery of chemotherapeutic agents. Chemical Reviews. ,vol. 109, pp. 3141- 3157 ,(2009) , 10.1021/CR900174J
Kun Yang, Yiyun Cheng, Xueyan Feng, Jiahai Zhang, Qinglin Wu, Tongwen Xu, Insights into the interactions between dendrimers and multiple surfactants: 5. Formation of miscellaneous mixed micelles revealed by a combination of 1H NMR, diffusion, and NOE analysis. Journal of Physical Chemistry B. ,vol. 114, pp. 7265- 7273 ,(2010) , 10.1021/JP1026493
Donald A. Tomalia, Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry Progress in Polymer Science. ,vol. 30, pp. 294- 324 ,(2005) , 10.1016/J.PROGPOLYMSCI.2005.01.007
Robert L. Lescanec, M. Muthukumar, Configurational characteristics and scaling behavior of starburst molecules: a computational study Macromolecules. ,vol. 23, pp. 2280- 2288 ,(1990) , 10.1021/MA00210A026
William D. Dozier, John S. Huang, Lewis J. Fetters, COLLOIDAL NATURE OF STAR POLYMER DILUTE AND SEMIDILUTE SOLUTIONS Macromolecules. ,vol. 24, pp. 2810- 2814 ,(1991) , 10.1021/MA00010A026
Wei-Ren Chen, Lionel Porcar, Yun Liu, Paul D. Butler, Linda J. Magid, Small Angle Neutron Scattering Studies of the Counterion Effects on the Molecular Conformation and Structure of Charged G4 PAMAM Dendrimers in Aqueous Solutions Macromolecules. ,vol. 40, pp. 5887- 5898 ,(2007) , 10.1021/MA0626564
Cameron C Lee, John A MacKay, Jean MJ Fréchet, Francis C Szoka, None, Designing dendrimers for biological applications Nature Biotechnology. ,vol. 23, pp. 1517- 1526 ,(2005) , 10.1038/NBT1171
Xin Li, Kunlun Hong, Yun Liu, Chwen-Yang Shew, Emily Liu, Kenneth W. Herwig, Gregory S. Smith, Junpeng Zhao, Guangzhao Zhang, Stergios Pispas, Wei-Ren Chen, Water distributions in polystyrene-block-poly[styrene-g-poly(ethylene oxide)] block grafted copolymer system in aqueous solutions revealed by contrast variation small angle neutron scattering study. Journal of Chemical Physics. ,vol. 133, pp. 144912- 144912 ,(2010) , 10.1063/1.3493331