Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation

作者: Paloma Bragado , Alejandro Armesilla , Augusto Silva , Almudena Porras

DOI: 10.1007/S10495-007-0082-8

关键词:

摘要: … p38α MAPK contributes to further activation of p53, which leads to a positive feedback loop, p38α MAPK/p53. We conclude that the p53/ROS/p38α MAPK cascade is essential for …

参考文章(42)
Motohiro Mihara, Susan Erster, Alexander Zaika, Oleksi Petrenko, Thomas Chittenden, Petr Pancoska, Ute M. Moll, p53 Has a Direct Apoptogenic Role at the Mitochondria Molecular Cell. ,vol. 11, pp. 577- 590 ,(2003) , 10.1016/S1097-2765(03)00050-9
Ute M Moll, Sonja Wolff, Daniel Speidel, Wolfgang Deppert, Transcription-independent pro-apoptotic functions of p53. Current Opinion in Cell Biology. ,vol. 17, pp. 631- 636 ,(2005) , 10.1016/J.CEB.2005.09.007
H. Christian Reinhardt, Aaron S. Aslanian, Jacqueline A. Lees, Michael B. Yaffe, p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage Cancer Cell. ,vol. 11, pp. 175- 189 ,(2007) , 10.1016/J.CCR.2006.11.024
J. Martin Brown, Laura D. Attardi, The role of apoptosis in cancer development and treatment response Nature Reviews Cancer. ,vol. 5, pp. 231- 237 ,(2005) , 10.1038/NRC1560
Jerry E Chipuk, Tomomi Kuwana, Lisa Bouchier-Hayes, Nathalie M Droin, Donald D Newmeyer, Martin Schuler, Douglas R Green, None, Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. ,vol. 303, pp. 1010- 1014 ,(2004) , 10.1126/SCIENCE.1092734
R Sanchez-Prieto, J M Rojas, Y Taya, J S Gutkind, A Role for the p38 Mitogen-activated Protein Kinase Pathway in the Transcriptional Activation of p53 on Genotoxic Stress by Chemotherapeutic Agents Cancer Research. ,vol. 60, pp. 2464- 2472 ,(2000)
Monica Hollstein, Manfred Hergenhahn, Qin Yang, Helmut Bartsch, Zhao-Qi Wang, Pierre Hainaut, New approaches to understanding p53 gene tumor mutation spectra Mutation Research. ,vol. 431, pp. 199- 209 ,(1999) , 10.1016/S0027-5107(99)00162-1
Hye-Gwang Jeong, Hyun-Ju Cho, In-Youb Chang, Sang-Pil Yoon, Young-Jin Jeon, Myung-Hee Chung, Ho Jin You, Rac1 prevents cisplatin-induced apoptosis through down-regulation of p38 activation in NIH3T3 cells. FEBS Letters. ,vol. 518, pp. 129- 134 ,(2002) , 10.1016/S0014-5793(02)02674-1
Dmitry V Bulavin, Shińichi Saito, M Christine Hollander, Kazuyasu Sakaguchi, Carl W Anderson, Ettore Appella, Albert J Fornace, Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation The EMBO Journal. ,vol. 18, pp. 6845- 6854 ,(1999) , 10.1093/EMBOJ/18.23.6845
Marie-Jeanne Pillaire, Angel R. Nebreda, Jean-Marie Darbon, Cisplatin and UV Radiation Induce Activation of the Stress-Activated Protein Kinase p38γ in Human Melanoma Cells☆ Biochemical and Biophysical Research Communications. ,vol. 278, pp. 724- 728 ,(2000) , 10.1006/BBRC.2000.3877