作者: Andreas W. Herling
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摘要: Purpose and Rationale The tunica muscularis mucosa preparation of the rat esophagus (Bieger Triggle 1985; Ohia et al. 1992) has been recommended for evaluation 5-HT4 receptor ligands since it possesses a homogeneous population receptors which mediates well-defined relaxant response to 5-HT (Baxter 1991; Baxter Clarke 1992; Reeves Waikar Eglen 1993, 1995; Yang 1993; Gale 1994; Monge Sagrada Elz Keller Hegde Cohen 1996, 1998; Wong 1996; Nagakura 1999; Takeda 1999).