α Subunit isoform influences GABAA receptor modulation by propofol

摘要: Abstract We have investigated the role of α subunit in modulation γ-aminobutyric acid type A (GABAA) receptors by general anesthetic propofol, using whole-cell patch clamp recordings made from distinct stable fibroblast cell lines which expressed only α1β3γ2 or α6β3γ2 GABAA receptors. At clinically relevant concentrations, propofol potentiated submaximal GABA currents to a far greater degree than those The influenced efficacy for modulation, but not its potency. In contrast, direct gating ion channel absence GABA, was significantly larger α6 α1 containing potentiation trichloroethanol, and methohexital also studied, showed same relative trends as propofol.