Immortalization and transformation of human cells.
作者： William C Hahn
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摘要: The disruption of homeostatic mechanisms that regulate normal cell growth and proliferation is a hallmark cancer. Experimentally, many the same genetic changes lead to abnormal conspire confer replicative immortality upon cells in culture. Correspondingly, several lines evidence implicate cellular immortalization as prerequisite for transformation. Recently much progress has been made elucidating machinery regulates lifespan. This review summarizes these recent advances our understanding molecular contribute human
参考文章(100)
Hayflick L, Mortality and immortality at the cellular level. A review. Biochemistry. ,vol. 62, pp. 1180- 1190 ,(1997)
Jacqueline J. L. Jacobs, Karin Kieboom, Silvia Marino, Ronald A DePinho, Maarten van Lohuizen, The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus Nature. ,vol. 397, pp. 164- 168 ,(1999) , 10.1038/16476
William C. Hahn, Sheila A. Stewart, Mary W. Brooks, Shoshana G. York, Elinor Eaton, Akiko Kurachi, Roderick L. Beijersbergen, Joan H.M. Knoll, Matthew Meyerson, Robert A. Weinberg, Inhibition of telomerase limits the growth of human cancer cells Nature Medicine. ,vol. 5, pp. 1164- 1170 ,(1999) , 10.1038/13495
A.M. Olovnikov, A theory of marginotomy: The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon Journal of Theoretical Biology. ,vol. 41, pp. 181- 190 ,(1973) , 10.1016/0022-5193(73)90198-7
L Hayflick, The illusion of cell immortality. British Journal of Cancer. ,vol. 83, pp. 841- 846 ,(2000) , 10.1054/BJOC.2000.1296
Woodring E. Wright, Jerry W. Shay, Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nature Medicine. ,vol. 6, pp. 849- 851 ,(2000) , 10.1038/78592
C M Counter, F M Botelho, P Wang, C B Harley, S Bacchetti, Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. Journal of Virology. ,vol. 68, pp. 3410- 3414 ,(1994) , 10.1128/JVI.68.5.3410-3414.1994
C.M. Counter, A.A. Avilion, C.E. LeFeuvre, N.G. Stewart, C.W. Greider, C.B. Harley, S. Bacchetti, Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. The EMBO Journal. ,vol. 11, pp. 1921- 1929 ,(1992) , 10.1002/J.1460-2075.1992.TB05245.X
William C. Hahn, Christopher M. Counter, Ante S. Lundberg, Roderick L. Beijersbergen, Mary W. Brooks, Robert A. Weinberg, Creation of human tumour cells with defined genetic elements Nature. ,vol. 400, pp. 464- 468 ,(1999) , 10.1038/22780
Ronald A. DePinho, The age of cancer Nature. ,vol. 408, pp. 248- 254 ,(2000) , 10.1038/35041694