Proteinase inhibitors block formation of pemphigus acantholysis in experimental models of neonatal mice and skin explants: effects of synthetic and plasma proteinase inhibitors on pemphigus acantholysis.

摘要: In organ culture experiments, the induction of pemphigus acantholysis is known to be blocked by addition serine proteinase inhibitors. Recently, nontoxic synthesized low molecular weight inhibitors have been clinically available for treatment disseminated intravascular coagulation and pancreatitis. To determine if these drugs are useful aids treat patients with pemphigus, we examined effect omega-guanidino ester analogues, i.e., 1) gabexate mesilate, 2) camostat 3) nafamostat on experimental in both neonatal BALB/c mice. Furthermore, plasma natural (alpha-1-proteinase inhibitor) isolated from human was similarly examined. Results revealed that (drugs) were able inhibit system, but had little or no lesion formation mouse system. By contrast, alpha-1-proteinase inhibitor could completely These findings implied a possible new therapeutic approach using pemphigus.