The three-year incidence of Non-B viral hepatitis morbidity in a controlled trial of pre-exposure immune serum globulin prophylaxis

摘要: A trial of pre-exposure immune serum globulin (ISG) vs. the prevailing policy post-exposure ISG for prevention viral hepatitis was undertaken among 23,447 male and female military recruits in Israel, an endemic area virus infection. We are reporting on three-year follow-up incidence non-B 12,835 recruits, half whom had been allocated to receive their first day service, while other served as a non-vaccinated (“regular care”) control group. Over period overall cumulative intervention group that (3.6 per 1000 7.2 1000; p=0.0037). Protection virtually absolute up nine months' follow-up. may have provided prolonged partial protection well excess six months. Between 10 18 months, many cases occurred controls. By months difference between study groups reached plateau highly significant (p=0.002). 19 36 case increment two similar. The benefit receiving remained evident three years after inception this indigenous population living area.