Decreased Hematocrit-To-Viscosity Ratio and Increased Lactate Dehydrogenase Level in Patients with Sickle Cell Anemia and Recurrent Leg Ulcers

摘要: Leg ulcer is a disabling complication in patients with sickle cell anemia (SCA) but the exact pathophysiological mechanisms are unknown. The aim of this study was to identify hematological and hemorheological alterations associated recurrent leg ulcers. Sixty-two SCA who never experienced ulcers (ULC-) 13 positive history (ULC+) - no at time were recruited. All steady state condition. Blood sampled perform hematological, biochemical (hemolytic markers) analyses (blood viscosity, red blood deformability aggregation properties). hematocrit-to-viscosity ratio (HVR), which reflects oxygen transport efficiency, calculated for each subject. Patients from ULC+ group older than ULC- group. Anemia (red count, hematocrit hemoglobin levels) more pronounced Lactate dehydrogenase level higher Neither nor RBC properties differed between two groups. HVR lower tended be reduced Our confirmed increased hemolytic rate recurrence. Furthermore, our data suggest that although systemic viscosity not major factor involved pathophysiology complication, decreased efficiency (i.e., low hematocrit/viscosity ratio) may play role.