Upper limit of serum ferritin: misinterpretation of the 2006 KDOQI anemia guidelines.

摘要: Intravenous iron treatment in hemodialysis patients improves response to recombinant human erythropoietin and facilitates achievement of targets for hemoglobin hematocrit. Excessive treatment, however, could expose risks related overload oxidative stress. Therefore, international guidelines generally recommend that intravenous (i.v.) be discontinued when serum ferritin is >500–1000 ng/ml. In the current review, relevant issues inform decisions as what levels should used upper limit are considered. A conclusion reached published literature inadequate developing evidence-based on this issue. Instead, clinical judgment critical properly weigh benefits i.v. determine whether appropriate a given patient with higher tests.