Developmental potency of gametic and embryonic genomes revealed by nuclear transfer.

摘要: Publisher Summary This chapter focuses on reproducible and easily performed nuclear transfer techniques that explore the role of major components fertilized eggs in mouse embryonic development. The essential contribution both male female genome to mammalian development was shown using method genetic analysis. Nuclear allowed dissection functionally unique zygote, also made possible analysis ability blastomere nuclei support normal after into zygote. Paternal maternal genomes are different complementary; thus, presence is required for complete It likely functional differences exist only small numbers specific genes, while most comparable. These somewhat unexpected results further emphasize need identification characterization which regulate early