Humanized mice as preclinical models for myeloid malignancies.
作者： Yuanbin Song , Stephanie Halene , Rana Gbyli
DOI: 10.1016/J.BCP.2020.113794
关键词:
摘要: Humanized mice have proven to be invaluable for human hematological translational research since they offer essential tools dissect disease biology and bridge the gap between pre-clinical testing of novel therapeutics their clinical applications. Many efforts been placed advance optimize humanized support engraftment, differentiation, maintenance hematopoietic stem cells (HSCs) system in order broaden scope applications such models. This review covers background mice, how are used as platforms model myeloid malignancies, various current potential approaches further enhance utilization biomedical research.
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