Optimum biased‐coin designs for sequential treatment allocation with covariate information
DOI: 10.1002/(SICI)1097-0258(19990730)18:14<1741::AID-SIM210>3.0.CO;2-F
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摘要: Randomized optimum designs of biased-coin type are compared with other strategies for the sequential allocation two or more treatments in a clinical trial. The emphasis is on variance estimated treatment contrasts. This variance, which depends design strategy employed may be interpreted as number patients whom information lost. Simulations provide clear plots evolution this loss during course
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