Multiparameter analyses of cell cycle regulatory proteins in human breast cancer: A key to definition of separate pathways in tumorigenesis

摘要: Breast cancer is one of the most common forms affecting many women. The disease nevertheless has widely varying behavior and therefore patient outcome, an important undertaking to define understand molecular mechanisms behind these actions. Defects in G1/S transition cell cycle affect both tumor proliferation fidelity check points responsible for chromosomal integrity DNA damage response lately been shown represent a rather limited set key aberrations transformation process. Many regulatory proteins are either oncogenes or suppressor genes closely associated types seem be different various cancers but often linked clinical behaviors. In this review role multiparameter analyses breast will outlined with special attention pattern as well definition two contrasting pathways tumorigenesis defined by cyclin D1 F overexpression.