Highly enantioselective organocatalytic cascade reaction for the synthesis of piperidines and oxazolidines
作者： Sylva Číhalová , Guillem Valero , Jiří Schimer , Marek Humpl , Martin Dračínský
DOI: 10.1016/J.TET.2011.08.079
关键词:
摘要: The synthesis of piperidines and derivatives in enantiopure fashion has been a challenging goal for organic chemists. In this report we developed nice cascade reaction piperidine based an amidomalonate Michael addition to enals followed by intramolecular hemiaminal formation with good yields enantioselectivities. Moreover studied the ‘in situ’ cyclization hemiaminals alcohols forming fused piperidine–oxazolidines.
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