Multi-residue analysis of drugs of abuse in wastewater and surface water by solid-phase extraction and liquid chromatography-positive electrospray ionisation tandem mass spectrometry.

摘要: A new-multi residue method was developed for the environmental monitoring of 65 stimulants, opiod and morphine derivatives, benzodiazepines, antidepressants, dissociative anaesthetics, drug precursors, human urine indicators their metabolites in wastewater surface water. The proposed analytical methodology offers rapid analysis a large number compounds, with low limits quantification utilises only one solid-phase extraction-ultra performance liquid chromatography-positive electrospray ionisation tandem mass spectrometry (SPE-LC-MS/MS) method, thus overcoming drawbacks previously published procedures. employed solid phase extraction usage Oasis MCX sorbent subsequent ultra spectrometry. 1.7 μm particle size column (1 mm×150 mm) resulted very flow rates (0.04 mLmin(-1)), as consequence gave good sensitivity, mobile consumption short retention times all compounds (from 2.9 to 23.1 min). High SPE recoveries (>60%) were obtained majority compounds. mean correlation coefficients calibration curves typically higher than 0.997 showed linearity range 0-1000 μgL(-1). detection ranged from 0.1 ngL(-1) including cocaine, benzoylecgonine, norbenzoylecgonine 2-oxo-3-hydroxy-LSD 100 caffeine. Method 0.5 154.2 ngL(-1). Intra- inter-day repeatabilities on average less 10%. accuracy within -33.1 30.1%. new multi-residue used analyse drugs abuse river water UK environment. Of targeted 46 analytes detected at levels above limit (MQL) treatment plant (WWTP) influent, 43 WWTP effluent 36