Chronic atrial fibrillation in the elderly: risks vs. benefits of long-term anticoagulation.

作者: D. Barry Wilson

DOI: 10.1111/J.1532-5415.1985.TB07121.X

关键词:

摘要: Chronic atrial fibrillation is generally thought to cause stroke by thrombus formation with subsequent embolization. Rheumatic heart disease previously led most cases of fibrillation, but recent substantial declines in the incidence rheumatic fever have changed distribution causes fibrillation. Elderly patients an appreciable prevalence chronic The risks and potential benefits long-term anti-coagulation for elderly are discussed quality evidence assessed. It concluded that sufficiently incomplete imperfect a large, well-designed trial be needed; however, this would difficult expensive.

参考文章(34)
J. A. Milliken, Atrial fibrillation and embolism Canadian Medical Association Journal. ,vol. 128, pp. 1370- 1372 ,(1983)
MJ Hayes, MJS Langman, AH Short, Changes in drug metabolism with increasing age: 1. warfarin binding and plasma proteins. British Journal of Clinical Pharmacology. ,vol. 2, pp. 69- 72 ,(1975) , 10.1111/J.1365-2125.1975.TB00474.X
Irving Freeman, Anticoagulants for Treatment of Atrial Fibrillation JAMA: The Journal of the American Medical Association. ,vol. 184, pp. 1007- 1010 ,(1963) , 10.1001/JAMA.1963.03700260039007
J. T. ECCLES, CONTROL OF WARFARIN THERAPY IN THE ELDERLY Age and Ageing. ,vol. 4, pp. 161- 166 ,(1975) , 10.1093/AGEING/4.3.161
Jerzy Gajewski, Mortality in an Insured Population With Atrial Fibrillation JAMA: The Journal of the American Medical Association. ,vol. 245, pp. 1540- 1544 ,(1981) , 10.1001/JAMA.1981.03310400022019
JOHN MARTIN ASKEY, THROMBOEMBOLISM ASSOCIATED WITH AURICULAR FIBRILLATION Journal of the American Medical Association. ,vol. 144, pp. 97- 100 ,(1950) , 10.1001/JAMA.1950.02920020017005
JOHN W. POLLARD, MICHAEL J. HAMILTON, NORMAN A. CHRISTENSEN, RICHARD W.P. ACHOR, Problems associated with long-term anticoagulant therapy. Observations in 139 cases. Circulation. ,vol. 25, pp. 311- 317 ,(1962) , 10.1161/01.CIR.25.2.311
AM Shepherd, DS Hewick, TA Moreland, IH Stevenson, Age as a determinant of sensitivity to warfarin. British Journal of Clinical Pharmacology. ,vol. 4, pp. 315- 320 ,(1977) , 10.1111/J.1365-2125.1977.TB00719.X