GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism.
作者： Nobuyuki Tanimura , Ruiqi Liao , Gary M. Wilson , Matthew R. Dent , Miao Cao
DOI: 10.1016/J.DEVCEL.2018.07.022
关键词:
摘要: By functioning as an enzyme cofactor, hemoglobin component, and gene regulator, heme is vital for life. One mode of heme-regulated transcription involves amplifying the activity GATA-1, a key determinant erythrocyte differentiation. To discover biological consequences metal cofactor-transcription factor mechanism, we merged GATA-1/heme-regulated sectors proteome transcriptome. This multi-omic analysis revealed GATA-1/heme circuit involving subunits, ubiquitination components, proteins not implicated in biology, including zinc exporter Slc30a1. Though GATA-1 induced expression Slc30a1 importer Slc39a8, Slc39a8 dominantly increased intracellular zinc, which conferred erythroblast survival. Subsequently, transporter switch, decreased sustained expression, reduced during terminal Downregulating and, strikingly, accelerated established conserved paradigm controls trace transport machinery levels mechanism governing cellular
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