Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice.

摘要: It has been demonstrated that physical exercise and probiotic supplementation delay the progress of Alzheimer's Disease (AD) in male APP/PS1TG mice. However, it also suggested both AD have systemic effects. We studied effects training treatment on microbiome biochemical signalling proteins liver. The results suggest liver is under oxidative stress, since SOD2 levels APP/PS1 mice were decreased when compared to a wild type Exercise prevented this decrease. did not find significant changes COX4, SIRT3, PGC-1a or GLUT4 levels, while pAMPK/AMPK, pmTOR/mTOR, pS6/S6 NRF2 randomly modulated. data probiotics-induced do strongly affect mitochondrial density protein synthesis-related AMPK/mTOR/S6 pathways these animals.