The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation
作者： Lily Peng , Matthew L. Eltgroth , Thomas J. LaTempa , Craig A. Grimes , Tejal A. Desai
DOI: 10.1016/J.BIOMATERIALS.2008.11.012
关键词:
摘要: In this study we investigate the effects of nanotubular titanium oxide (TiO(2)) surfaces on vascular cells. EC and VSMC response to nanotubes was investigated through immunofluorescence staining, scanning electron microscopy, 5-ethynyl-2'-deoxyuridine proliferation assays, prostaglandin I(2) (PGI(2)) enzyme immunoassays. We found that surface significantly enhances secretion PGI(2). The also results in a decrease increased expression smooth muscle alpha-actin. These data suggest engineered nanotopographical cues may influence both behavior manner be useful for stent or other applications.
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