The IncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer.

摘要: Long noncoding RNAs (IncRNAs) are increasingly implicated in cancer biology, contributing to essential cell functions such as proliferation, invasion, and metastasis. In prostate cancer, several lncRNAs have been nominated critical actors disease pathogenesis. Among these, expression of PCGEM1 PRNCR1 has identified a possible component progression through the coordination androgen receptor (AR) signaling (Yang et al., Nature 2013, see ref. [1]). However, concerns regarding robustness these findings suggested. Here, we sought evaluate whether associated with cancer. Through comprehensive analysis RNA-sequencing data (RNA-seq), find evidence that but not is We employ large cohort >230 high-risk patients long-term outcomes show that, contrast prior reports, neither gene poor patient outcomes. further observe no nor interact AR, AR signaling. Thus, conclusively demonstrate prognostic refute suggestions