Dietary phyto-oestrogens and the risk of ovarian and endometrial cancers: findings from two Australian case-control studies.

摘要: Phyto-oestrogens have been suggested to a protective effect on hormone-sensitive cancers. However, few studies investigated the association between dietary phyto-oestrogens and gynaecological In present study, we analysed data from two population-based case-control of ovarian (1366 cases 1414 controls) endometrial (1288 1435 Dietary intake information was obtained using 135-item FFQ, phyto-oestrogen estimated published food composition databases. Unconditional logistic regression used estimate adjusted OR 95% CI. multivariable analyses, there suggestive pattern inverse associations increasing intakes total phyto-oestrogens, isoflavones enterolignans risk cancer. results only reached statistical significance for lignan compounds matairesinol lariciresinol, where highest v. lowest category 0.72 (95% CI 0.54, 0.96; P trend = 0.02) 0.55, 0.03) lariciresinol. When cancer assessed by subtype, an indication that may be associated with decreased mucinous (cases n 158) tumours (OR category: 0.47 0.24, 0.93); 0.04). were no significant other histological subtypes. contrast, (total or any subclass) unrelated overall subtype.