Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression
作者： Ki-Jong Rhee , Jong Lee , Young Eom
关键词:
摘要: Mesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many studies have reported that tumor progression and metastasis increase by MSCs. In contrast, other shown MSCs suppress growth contribute to promotion several mechanisms: (1) transition tumor-associated fibroblasts; (2) suppression immune response; (3) angiogenesis; (4) stimulation epithelial-mesenchymal (EMT); (5) contribution the microenvironment; (6) inhibition cell apoptosis; (7) metastasis. contrast tumor-promoting properties, inhibit increasing inflammatory infiltration, inhibiting angiogenesis, suppressing Wnt signaling AKT signaling, inducing cycle arrest apoptosis. this review, we will discuss potential mechanisms which MSC mediates support or then possible tumor-specific therapeutic strategies using as delivery vehicles, based on their homing
mdpi.com
doaj.org
elsevier.com
core.ac.uk 参考文章(215)
Paola Secchiero, Sonia Zorzet, Claudio Tripodo, Federica Corallini, Elisabetta Melloni, Lorenzo Caruso, Raffaella Bosco, Sabrina Ingrao, Barbara Zavan, Giorgio Zauli, Human Bone Marrow Mesenchymal Stem Cells Display Anti-Cancer Activity in SCID Mice Bearing Disseminated Non-Hodgkin's Lymphoma Xenografts PLoS ONE. ,vol. 5, pp. e11140- ,(2010) , 10.1371/JOURNAL.PONE.0011140
Keon Hee Yoo, In Keun Jang, Myoung Woo Lee, Hyo Eun Kim, Mal Sook Yang, Youngwoo Eom, Jong Eun Lee, Young Jin Kim, Seong Kyu Yang, Hye Lim Jung, Ki Woong Sung, Cheol Woo Kim, Hong Hoe Koo, Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues Cellular Immunology. ,vol. 259, pp. 150- 156 ,(2009) , 10.1016/J.CELLIMM.2009.06.010
Cong Cong, Sheng-fu Li, Dan Long, Wei-dong Tan, Ying-qiu Mao, Jie Zhang, You-ping Li, Jing-qiu Cheng, Yan-rong Lu, Yu Yuan, Xiu-jie Wang, Ling-ling Wei, You-nan Chen, The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo. Cancer Biology & Therapy. ,vol. 7, pp. 245- 251 ,(2008) , 10.4161/CBT.7.2.5296
S.E. Haynesworth, J. Goshima, V.M. Goldberg, A.I. Caplan, Characterization of cells with osteogenic potential from human marrow. Bone. ,vol. 13, pp. 81- 88 ,(1992) , 10.1016/8756-3282(92)90364-3
L. C. Cantley, The Phosphoinositide 3-Kinase Pathway Science. ,vol. 296, pp. 1655- 1657 ,(2002) , 10.1126/SCIENCE.296.5573.1655
Sergio Dias, Sergey V. Shmelkov, George Lam, Shahin Rafii, VEGF165 promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition Blood. ,vol. 99, pp. 2532- 2540 ,(2002) , 10.1182/BLOOD.V99.7.2532
Isao Sakaida, Shuji Terai, Naoki Yamamoto, Koji Aoyama, Tsuyoshi Ishikawa, Hiroshi Nishina, Kiwamu Okita, Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology. ,vol. 40, pp. 1304- 1311 ,(2004) , 10.1002/HEP.20452
Reto M. Baertschiger, Véronique Serre-Beinier, Philippe Morel, Domenico Bosco, Marion Peyrou, Sophie Clément, Antonino Sgroi, André Kaelin, Leo H. Buhler, Carmen Gonelle-Gispert, Fibrogenic Potential of Human Multipotent Mesenchymal Stromal Cells in Injured Liver PLoS ONE. ,vol. 4, pp. e6657- ,(2009) , 10.1371/JOURNAL.PONE.0006657
Rodrigo Haddad, Felipe Saldanha-Araujo, Mechanisms of T-cell immunosuppression by mesenchymal stromal cells: what do we know so far? BioMed Research International. ,vol. 2014, pp. 216806- 216806 ,(2014) , 10.1155/2014/216806
Jean Paul Thiery, Epithelial–mesenchymal transitions in tumour progression Nature Reviews Cancer. ,vol. 2, pp. 442- 454 ,(2002) , 10.1038/NRC822