Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade

摘要: The development of gastritis is associated with an increased risk gastric cancer. Current invasive diagnostic methods are not suitable for monitoring progress. In this work based on 78 patients and 50 healthy individuals, we observed that the variation tongue-coating microbiota was occurrence gastritis. Twenty-one microbial species were identified differentiating microbiomes individuals. Pathways such as metabolism in diverse environments, biosynthesis antibiotics bacterial chemotaxis up-regulated patients. abundance Campylobacter concisus found precancerous cascade. Furthermore, could be detected tongue coating fluid a validation cohort containing 38 These observations provided biological evidence diagnosis traditional Chinese medicine, indicated microbiome potential non-invasive biomarker, which might long-term