New class of antifungal agents: jasplakinolide, a cyclodepsipeptide from the marine sponge, Jaspis species.

摘要: Jasplakinolide is a cyclodepsipeptide which represents new class of antifungal agents with potent activity against Candida albicans. fungicidal C. albicans both MIC and minimum lethal concentration 25 micrograms/ml in broth dilution assay. This compares to that the imidazole miconazole nitrate, had 6.2 50 same Topical administration 2% jasplakinolide cream murine vaginal infection was equivalent efficacy nitrate at 2%. Subcutaneous not effective systemic infection.