Triazole-Linked Analogues of DNA and RNA (TLDNA and TLRNA): Synthesis and Functions
作者： Hiroyuki Isobe , Tomoko Fujino
关键词:
摘要: Click chemistry has provided us with access to DNA and RNA analogues non-natural triazole internucleoside linkages. The bond periodicity of the oligonucleotides was designed enforce duplex formation natural congeners, non-cleavable linkages protect oligomers against nuclease digestion. This account reviews progress triazole-linked over past five years. Reinforced by their synthetic robustness, these may find various utilities as tools for exploratory research.
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