Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes.
作者： Ryosuke Sugiyama , Shinichi Nishimura , Nobuaki Matsumori , Yuta Tsunematsu , Akira Hattori
DOI: 10.1021/JA500128U
关键词:
摘要: Polyene macrolactams are a class of microbial metabolites, many which show potent biological activities with unidentified modes action. Here we report that 8-deoxyheronamide C, new 20-membered polyene macrolactam from marine-derived actinomycete Streptomyces sp., is unique membrane binder. 8-Deoxyheronamide C showed characteristic sensitivity profile against fission yeast sterol mutant cells, indicating the metabolite targets cell membranes. We detected tight physical interaction between heronamides including and heronamide saturated hydrocarbon chains in lipid membranes using surface plasmon resonance experiments. further induced abnormal wall morphology probably by perturbing structure microdomains. This work will accelerate medical investigation macrolactams.
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