Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
作者： Kevin Gunderson
DOI:
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摘要: The invention provides methods of identifying a plurality reactive recognition sites for restriction endonuclease in genomic DNA. In particular embodiments, the can be used to identify methylation state CpG target method include steps treating DNA with endonuclease, thereby producing fragments; ligating fragments, forming concatenated DNA; and sequence portions that are re-ordered compared
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