A novel drug-polyethylene glycol liquid compound method to prepare 10-hydroxycamptothecin loaded human serum albumin nanoparticle

摘要: Drug loading strategies and the methods derived for implementing those are crucially important to preparation of drug loaded human serum albumin nanoparticles (HSA-NPs), because each them is focused on wrapping up specific types drugs via certain physical chemical properties. However, poor adaptability still exists load like model substance 10-hydroxycamptothecin (HCPT) by conventional methods. Because it typically represents a large class water-insoluble drugs, who also structurally possess number hydrophilic groups. So even though they majorly have lipophilicity but low liposolubility. This article presents new concept strategy that takes polymer liquid compound as medium. The was made from weight polyethylene glycol (l-PEG) HCPT. Consequently, this has managed fabricate HCPT-loaded HSA-NPs through an unconventional approach overcomes drawbacks current means better results been obtained, high entrapment efficiency (over 99%) less toxicity involvement. Afterward, in vitro vivo evaluations characterizations were performed help with in-depth interpretation mechanism order reveal further investigate possible far-reaching applications method.