Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells.
作者： Ting Chan , Ling Zhu , Michele C Madigan , Ke Wang , Weiyong Shen
DOI: 10.1111/BPH.13060
关键词:
摘要: Background and Purpose Vision depends on retinoid exchange between the retinal pigment epithelium (RPE) photoreceptors. Defects in any step of canonical visual cycle can lead to degenerations. All-trans-retinol (atROL) plays an important role signal transduction. However, how atROL enters human RPE from apical membrane remains unclear. This study investigated organic anion transporting polypeptide 1A2 (OATP1A2) uptake RPE.
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